Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837386 | 1.00 | ADORA1 (0.40) | ADORA1ATMSCN4AMAPTKDM4E | |
| SCHEMBL5838794 | 0.80 | ADORA1 (0.51) | ADORA1SCN4AMAPTKDM4EGAA | |
| SCHEMBL5838020 | 0.80 | ADORA1 (0.49) | ADORA1SCN4AMAPTKDM4EGAA | |
| SCHEMBL5837408 | 0.80 | ADORA1 (0.51) | ADORA1SCN4AMAPTKDM4EGAA | |
| SCHEMBL5838302 | 0.77 | HDAC8 (0.49) | ADORA1MAPTKDM4E | |
| SCHEMBL5837548 | 0.72 | ADORA1 (0.51) | ADORA1MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL6049948 | 0.72 | ADORA1 (0.51) | ADORA1MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL5838237 | 0.71 | ADORA1 (0.46) | ADORA1MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL29839794 | 0.67 | ADORA1 (0.66) | ADORA1MAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL29839789 | 0.67 | ADORA1 (0.66) | ADORA1MAPTKDM4EGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |