Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 17/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 12/20 | 0.48 |
| ▸ | PTPRA | P18433 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | UGCG | Q16739 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837463 | 0.90 | PTPN1 (0.42) | PTPN1PTPN2PTPRAPTPRCPARP1 | |
| SCHEMBL5838412 | 0.90 | PTPN1 (0.42) | PTPN1PTPN2PTPRAPTPRCPARP1 | |
| SCHEMBL5838018 | 0.90 | PTPN1 (0.42) | PTPN1PTPN2PTPRAPTPRCPARP1 | |
| SCHEMBL5837663 | 0.87 | PTPN1 (0.40) | PTPN1PTPN2PTPRAPTPRCPARP1 | |
| SCHEMBL5837799 | 0.86 | PTPN1 (0.46) | PTPN1PTPN2PTPRAPTPRC | |
| SCHEMBL7535281 | 0.85 | PARP1 (0.36) | PTPN1PTPN2PARP1NR1I2UGCG | |
| SCHEMBL5837583 | 0.84 | PTPN1 (0.44) | PTPN1PTPN2PTPRAPTPRC | |
| SCHEMBL5837530 | 0.84 | PTPN1 (0.44) | PTPN1PTPN2PTPRAPTPRC | |
| SCHEMBL5837650 | 0.78 | PTPN1 (0.41) | PTPN1PTPN2PTPRAPTPRC | |
| SCHEMBL5838719 | 0.78 | PTPN1 (0.41) | PTPN1PTPN2PTPRAPTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | claimed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | claimed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | claimed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | claimed |
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |