Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772980 | 0.78 | MAPT (0.39) | MAPTKDM4ENT5EADORA1MEN1 | |
| SCHEMBL7521524 | 0.77 | ADORA1 (0.46) | MAPTKDM4EADORA1MEN1KMT2A | |
| SCHEMBL5837487 | 0.75 | KDM4E (0.37) | MAPTKDM4ENT5EADORA1MEN1 | |
| SCHEMBL5837857 | 0.74 | MAPT (0.41) | MAPTKDM4ENT5EADORA1MEN1 | |
| SCHEMBL5837057 | 0.74 | KDM4E (0.46) | MAPTKDM4ENT5EADORA1MEN1 | |
| SCHEMBL7528917 | 0.74 | KDM4E (0.46) | MAPTKDM4ENT5EADORA1MEN1 | |
| SCHEMBL5772973 | 0.73 | MAPT (0.41) | MAPTKDM4EADORA1MEN1KMT2A | |
| SCHEMBL5838328 | 0.73 | KDM4E (0.40) | MAPTKDM4ENT5EADORA1MEN1 | |
| SCHEMBL5837854 | 0.71 | MAPT (0.38) | MAPTKDM4ENT5EHCRTR1ADORA1 | |
| SCHEMBL5838415 | 0.70 | KDM4E (0.38) | MAPTKDM4ENT5EADORA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |