Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837501 | 1.00 | ADORA1 (0.39) | ADORA1MAPTMEN1LMNAKMT2A | |
| SCHEMBL7513980 | 0.87 | MCHR1 (0.37) | ADORA1MAPTGRM6KDM4ECXCR2 | |
| SCHEMBL7513983 | 0.87 | MCHR1 (0.37) | ADORA1MAPTGRM6KDM4ECXCR2 | |
| SCHEMBL5838733 | 0.84 | ADORA1 (0.42) | ADORA1MAPTMEN1LMNAKMT2A | |
| SCHEMBL5770130 | 0.84 | ADORA1 (0.42) | ADORA1MAPTMEN1LMNAKMT2A | |
| SCHEMBL7735418 | 0.84 | ADORA1 (0.42) | ADORA1MAPTMEN1LMNAKMT2A | |
| SCHEMBL5770132 | 0.84 | ADORA1 (0.42) | ADORA1MAPTMEN1LMNAKMT2A | |
| SCHEMBL7517368 | 0.84 | ADORA1 (0.42) | ADORA1MAPTMEN1LMNAKMT2A | |
| SCHEMBL5771598 | 0.79 | ADORA1 (0.38) | ADORA1MAPTMEN1LMNAKMT2A | |
| SCHEMBL5770553 | 0.79 | ADORA1 (0.38) | ADORA1MAPTMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |