Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837052 | 1.00 | HSD17B10 (0.40) | HSD17B10NR1H2NPC1UCHL1SCN4A | |
| SCHEMBL30289230 | 0.86 | HSD17B10 (0.41) | HSD17B10NR1H2NPC1UCHL1SCN4A | |
| SCHEMBL8235326 | 0.86 | HSD17B10 (0.41) | HSD17B10NR1H2NPC1UCHL1SCN4A | |
| SCHEMBL19390003 | 0.86 | NPC1 (0.41) | HSD17B10NR1H2NPC1UCHL1SCN4A | |
| SCHEMBL4869226 | 0.86 | HSD17B10 (0.47) | HSD17B10NR1H2NPC1UCHL1SCN4A | |
| SCHEMBL4547486 | 0.86 | HSD17B10 (0.47) | HSD17B10NR1H2NPC1UCHL1SCN4A | |
| SCHEMBL15606327 | 0.86 | HSD17B10 (0.47) | HSD17B10NR1H2NPC1UCHL1SCN4A | |
| SCHEMBL10215478 | 0.86 | NPC1 (0.41) | HSD17B10NR1H2NPC1UCHL1SCN4A | |
| SCHEMBL17358752 | 0.86 | HSD17B10 (0.41) | HSD17B10NR1H2NPC1UCHL1SCN4A | |
| Tert-Butylamine SCHEMBL28919678 | 0.85 | HSD17B10 (0.44) | HSD17B10NR1H2NPC1UCHL1SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |