Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 12/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 7/20 | 0.37 |
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049948 | 0.91 | ADORA1 (0.51) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL5837548 | 0.91 | ADORA1 (0.51) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL5838237 | 0.83 | ADORA1 (0.46) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL5837958 | 0.80 | ADORA1 (0.48) | ADORA1MAPTKDM4EGRM6GAA | |
| SCHEMBL7520724 | 0.79 | ADORA1 (0.45) | ADORA1MAPTALDH1A1GRM6HPGD | |
| SCHEMBL5837408 | 0.78 | ADORA1 (0.51) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL5838794 | 0.78 | ADORA1 (0.51) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL7528917 | 0.77 | KDM4E (0.46) | ADORA1MAPTALDH1A1KDM4EGRM6 | |
| SCHEMBL5839242 | 0.76 | GRM6 (0.43) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL5838020 | 0.76 | ADORA1 (0.49) | ADORA1MAPTALDH1A1KDM4ERAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |