Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837940 | 0.94 | PTPN1 (0.54) | PTPN1PTPN2NPC1RAB9AKDM4E | |
| SCHEMBL5838164 | 0.92 | PTPN1 (0.49) | PTPN1PTPN2NPC1RAB9AKDM4E | |
| SCHEMBL7558300 | 0.86 | KMT2A (0.42) | PTPN1NPC1RAB9AKDM4EKMT2A | |
| SCHEMBL5837651 | 0.85 | DRD4 (0.46) | PTPN1PTPN2MAPT | |
| SCHEMBL5838423 | 0.85 | MEN1 (0.44) | PTPN1PTPN2KMT2AMEN1DRD3 | |
| SCHEMBL5837796 | 0.84 | PTPN1 (0.46) | PTPN1PTPN2NPC1RAB9AKMT2A | |
| SCHEMBL5837772 | 0.84 | PTPN1 (0.47) | PTPN1PTPN2KMT2AMAPT | |
| SCHEMBL7526850 | 0.84 | PTPN1 (0.46) | PTPN1PTPN2NPC1RAB9AKDM4E | |
| SCHEMBL5837693 | 0.83 | KMT2A (0.46) | PTPN1PTPN2NPC1RAB9AKMT2A | |
| SCHEMBL7553313 | 0.80 | KDM4E (0.43) | PTPN1NPC1RAB9AKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | claimed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | claimed |
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |