Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837698 | 0.85 | CXCR2 (0.38) | THRBCXCR2NT5EMAPT | |
| SCHEMBL5837185 | 0.81 | NT5E (0.38) | THRBCXCR2NT5EPOLBMAPT | |
| SCHEMBL5837373 | 0.80 | CXCR2 (0.36) | THRBCXCR2NT5EMAPT | |
| SCHEMBL5837377 | 0.79 | CXCR2 (0.36) | THRBCXCR2NT5E | |
| SCHEMBL5838328 | 0.68 | KDM4E (0.40) | NT5EMAPT | |
| SCHEMBL6315579 | 0.68 | CXCR2 (0.44) | CXCR2NT5EMAPT | |
| SCHEMBL5837805 | 0.68 | NT5E (0.41) | THRBCXCR2NT5EMAPT | |
| SCHEMBL5837189 | 0.66 | NT5E (0.34) | THRBCXCR2NT5EMAPT | |
| SCHEMBL5838260 | 0.65 | NT5E (0.38) | THRBCXCR2NT5EMAPT | |
| SCHEMBL5836747 | 0.65 | NT5E (0.38) | THRBCXCR2NT5EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |