Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 14/20 | 0.83 |
| ▸ | RBPJ | Q06330 | 4/20 | 0.83 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.79 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.79 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.79 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.79 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.79 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.79 |
| ▸ | NOTCH3 | Q9UM47 | 10/20 | 0.72 |
| ▸ | CCKBR | P32239 | 2/20 | 0.64 |
| ▸ | NOTCH2 | Q04721 | 1/20 | 0.60 |
| ▸ | NOTCH4 | Q99466 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8244069 | 1.00 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3293655 | 1.00 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287317 | 1.00 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287486 | 1.00 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287198 | 1.00 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3289695 | 0.94 | NOTCH1 (0.74) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287168 | 0.94 | NOTCH1 (0.73) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4110386 | 0.94 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3286032 | 0.94 | NOTCH1 (0.73) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3290462 | 0.94 | NOTCH1 (0.73) | NOTCH1RBPJPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878363-B2 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-04-12 | — | — | US | claimed |
| US-7153491-B2 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2006-12-26 | — | — | US | disclosed |
| EP-1589342-A2 | Use of radioligands to screen inhibitors of amyloid-beta peptide production | Bristol-Myers Squibb Pharma Company (US) | 2005-10-26 | — | — | EP | disclosed |
| EP-1129355-B1 | USE OF RADIOLIGANDS TO SCREEN INHIBITORS OF AMYLOID-BETA PEPTIDE PRODUCTION | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2005-07-20 | — | — | EP | disclosed |
| US-20050129612-A1 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | ZACZEK ROBERT (US) | 2005-06-16 | — | — | US | disclosed |
| US-6878363-B2 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-04-12 | — | — | US | disclosed |
| US-20050019255-A1 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | ZACZEK ROBERT (US) | 2005-01-27 | — | — | US | disclosed |
| US-6737038-B1 | CONTACTING POTENTIAL INHIBITOR AND TAGGED INHIBITOR OF BETA-AMYLOID PRODUCTION WITH MACROMOLECULE CONTAINING BINDING SITE SPECIFIC FOR TAGGED INHIBITOR, SEPARATING BOUND INHIBITOR, DETERMINING INHIBITORY CONCENTRATION | BRISTOL-MYERS SQUIBB COMPANY | 2004-05-18 | — | — | US | disclosed |
| US-20020159947-A1 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | LANTHEUS MEDICAL IMAGING, INC. | 2002-10-31 | — | — | US | disclosed |
| US-6331408-B1 | CONTACTING A POTENTIAL INHIBITOR OF BETA-AMYLOID PRODUCTION AND TAGGED INHIBITOR OF BETA-AMYLOID PRODUCTION WITH AT MACROMOLECULE INVOLVED IN PROCESSING OF AMYLOID PRECURSOR PROTEIN; SEPARATING TAGGED INHIBITOR, DETERMINING | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2001-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020159947-A1 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | APP, BACE1, BACE2 | NOTCH1 79/4885RBPJ 3612/4885PSEN1 5/4885 |
| US-20050019255-A1 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | APP, BACE1, BACE2 | NOTCH1 100/4885RBPJ 3587/4885PSEN1 4/4885 |
| US-20050129612-A1 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | APP, BACE1, BACE2 | NOTCH1 63/4885RBPJ 3433/4885PSEN1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.