Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 11/20 | 0.73 |
| ▸ | PRKCA | P17252 | 2/20 | 0.73 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.63 |
| ▸ | CDK2 | P24941 | 9/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840578 | 1.00 | CDK1 (0.73) | CDK1PRKCAPDGFRACCNE1CDK2 | |
| SCHEMBL5839191 | 1.00 | CDK1 (0.73) | CDK1PRKCAPDGFRACCNE1CDK2 | |
| SCHEMBL5840462 | 0.92 | CDK1 (0.73) | CDK1PRKCAPDGFRACCNE1CDK2 | |
| SCHEMBL5840457 | 0.92 | CDK1 (0.73) | CDK1PRKCAPDGFRACCNE1CDK2 | |
| SCHEMBL5840171 | 0.87 | CDK1 (0.74) | CDK1PRKCACCNE1CDK2EGFR | |
| SCHEMBL5840164 | 0.87 | CDK1 (0.74) | CDK1PRKCACCNE1CDK2EGFR | |
| SCHEMBL5839320 | 0.86 | CDK1 (0.82) | CDK1PRKCAPDGFRACCNE1CDK2 | |
| SCHEMBL7203055 | 0.86 | CDK1 (0.82) | CDK1PRKCAPDGFRACCNE1CDK2 | |
| SCHEMBL5839316 | 0.86 | CDK1 (0.82) | CDK1PRKCAPDGFRACCNE1CDK2 | |
| SCHEMBL5840521 | 0.84 | CDK1 (1.00) | CDK1PRKCAPDGFRACCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |