Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4578424 | 0.85 | SMN1; SMN2 (0.82) | SMN1; SMN2USP2HTTKDM4EHSD17B10 | |
| SCHEMBL5840433 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2USP2HTTKDM4EHSD17B10 | |
| SCHEMBL8429732 | 0.82 | SMN1; SMN2 (0.72) | SMN1; SMN2USP2HTTKDM4EHSD17B10 | |
| SCHEMBL8457542 | 0.82 | SMN1; SMN2 (0.72) | SMN1; SMN2USP2HTTKDM4EHSD17B10 | |
| SCHEMBL23929061 | 0.81 | SMN1; SMN2 (0.82) | SMN1; SMN2USP2HTTKDM4EHSD17B10 | |
| SCHEMBL4578420 | 0.81 | SMN1; SMN2 (0.82) | SMN1; SMN2USP2HTTKDM4EHSD17B10 | |
| SCHEMBL10655587 | 0.81 | HSD17B10 (0.62) | SMN1; SMN2KDM4EHSD17B10KMT2ATSHR | |
| SCHEMBL7742640 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2USP2HTTKDM4EHSD17B10 | |
| SCHEMBL8616990 | 0.79 | SMN1; SMN2 (0.79) | SMN1; SMN2USP2HTTKDM4EHSD17B10 | |
| SCHEMBL31053557 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2USP2HTTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135502-B1 | Colchinol derivatives as vascular damaging agents | ANGIOGENE PHARMACEUTICALS LTD. (GB) | 2006-11-14 | — | — | US | disclosed |
| US-20060128633-A1 | Colchinol derivatives as vascular damaging agents | ANGIOGENE PHARMACEUTICALS LTD. | 2006-06-15 | — | — | US | disclosed |
| EP-1140745-B1 | COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS | ANGIOGENE PHARM LTD (GB) | 2003-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128633-A1 | Colchinol derivatives as vascular damaging agents | NR1H3, NR1H2, NR1H4 | SMN1; SMN2 2267/4885USP2 3692/4885HTT 3597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.