Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 12/20 | 0.54 |
| ▸ | CDK2 | P24941 | 12/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 11/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.54 |
| ▸ | CDK1 | P06493 | 8/20 | 0.54 |
| ▸ | PRKCA | P17252 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840725 | 1.00 | CCNA2 (0.54) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5839860 | 0.91 | CDK1 (0.67) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5839851 | 0.91 | CDK1 (0.67) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5840318 | 0.90 | CCNA2 (0.61) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5840307 | 0.90 | CCNA2 (0.61) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5839099 | 0.84 | CDK1 (0.70) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5839091 | 0.84 | CDK1 (0.70) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5839936 | 0.83 | CDK5 (0.56) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5839952 | 0.83 | CDK5 (0.56) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5840504 | 0.83 | CDK2 (0.62) | CCNA2CDK2CCNA1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |