SCHEMBL5840733

SCHEMBL5840733

CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@@H](N)CC3)nc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 11/20 1.00
PRKCA P17252 3/20 1.00
CCNE1 P24864 8/20 0.84
CDK2 P24941 8/20 0.84
PDGFRA P16234 7/20 0.84
EGFR P00533 2/20 0.81
CLK1 P49759 3/20 0.75
CLK2 P49760 3/20 0.75
CCNB1 P14635 2/20 0.75
CLK4 Q9HAZ1 2/20 0.75
NPC1 O15118 1/20 0.75
CCNT1 O60563 1/20 0.75
CDK4 P11802 1/20 0.75
EIF2AK2 P19525 1/20 0.75
CCNA2 P20248 1/20 0.75
CCND1 P24385 1/20 0.75
CCND3 P30281 1/20 0.75
MTOR P42345 1/20 0.75
CDK7 P50613 1/20 0.75
CDK9 P50750 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8707068 1.00 CDK1 (1.00) CDK1PRKCACCNE1CDK2PDGFRA
SCHEMBL5839422 1.00 CDK1 (1.00) CDK1PRKCACCNE1CDK2PDGFRA
SCHEMBL5840026 0.92 CDK1 (0.85) CDK1PRKCACCNE1CDK2PDGFRA
SCHEMBL5840382 0.91 CDK1 (1.00) CDK1PRKCACCNE1CDK2PDGFRA
SCHEMBL5839900 0.91 CDK1 (0.83) CDK1PRKCACCNE1CDK2PDGFRA
SCHEMBL8710781 0.90 CDK1 (1.00) CDK1PRKCACCNE1CDK2PDGFRA
SCHEMBL5841943 0.90 CDK1 (1.00) CDK1PRKCACCNE1CDK2PDGFRA
SCHEMBL5841952 0.90 CDK1 (1.00) CDK1PRKCACCNE1CDK2PDGFRA
SCHEMBL8710789 0.90 CDK1 (1.00) CDK1PRKCACCNE1CDK2PDGFRA
SCHEMBL5839623 0.90 CDK1 (1.00) CDK1PRKCACCNE1CDK2PDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7091346-B1 Purine derivatives and processes for their preparation NOVARTIS AG (CH) 2006-08-15 US disclosed
EP-0874846-B1 PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION NOVARTIS AG (CH) 2003-04-02 EP disclosed
EP-0874846-A1 PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION Novartis AG (CH) 1998-11-04 EP disclosed
WO-1997016452-A1 PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION NOVARTIS AG (CH) 1997-05-09 WO disclosed