Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.49 |
| ▸ | FCER2 | P06734 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5841215 | 1.00 | SYK (0.52) | SYKNTRK1CDK1CCNB1CCNA2 | |
| SCHEMBL5183073 | 0.89 | SYK (0.66) | SYKNTRK1CDK1CCNB1CCNA2 | |
| SCHEMBL5183066 | 0.89 | SYK (0.66) | SYKNTRK1CDK1CCNB1CCNA2 | |
| SCHEMBL5183887 | 0.87 | SRC (0.54) | SYKNTRK1CDK1CCNB1CCNA2 | |
| SCHEMBL5430091 | 0.87 | SRC (0.54) | SYKNTRK1CDK1CCNB1CCNA2 | |
| SCHEMBL5181573 | 0.87 | SRC (0.65) | SYKNTRK1CDK1CCNB1CCNA2 | |
| SCHEMBL5181577 | 0.87 | SRC (0.65) | SYKNTRK1CDK1CCNB1CCNA2 | |
| SCHEMBL5203968 | 0.85 | PDPK1 (0.57) | SYKNTRK1CDK1CCNB1CCNA2 | |
| SCHEMBL6405756 | 0.83 | ALK (0.56) | SYKNTRK1CDK1CCNB1CCNA2 | |
| SCHEMBL6405753 | 0.83 | ALK (0.56) | SYKNTRK1CDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071332-B2 | Indolinone derivatives as protein kinase/phosphatase inhibitors | SUGEN, INC. (US) | 2006-07-04 | — | — | US | disclosed |