Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 19/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6209552 | 0.95 | C1S (0.50) | C1SF2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6209297 | 0.91 | C1S (0.49) | C1SF2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6209301 | 0.91 | C1S (0.48) | C1SF2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6211999 | 0.90 | C1S (0.46) | C1SF2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6208090 | 0.87 | C1S (0.45) | C1SF2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6210224 | 0.87 | C1S (0.43) | C1SF2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6209814 | 0.85 | C1S (0.47) | C1SF2F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL5981373 | 0.81 | C1S (0.66) | C1S | |
| Trifluoroacetic Acid SCHEMBL5841092 | 0.79 | C1S (0.75) | C1S | |
| Trifluoroacetic Acid SCHEMBL6210839 | 0.78 | PRSS1 (0.45) | C1SF2F10PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109354-B2 | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-09-19 | — | — | US | disclosed |