Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842493 | 0.93 | MAPT (0.46) | MAPTTP53POLBALDH1A1L3MBTL1 | |
| SCHEMBL5848032 | 0.87 | MEN1 (0.48) | MAPTTP53POLBALDH1A1L3MBTL1 | |
| SCHEMBL5842301 | 0.84 | MAPT (0.52) | MAPTTP53ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL5843024 | 0.84 | KMT2A (0.46) | MAPTPOLBALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5841812 | 0.82 | MAPT (0.48) | MAPTPOLBALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL5842505 | 0.78 | MAPT (0.64) | MAPTTP53ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL5841226 | 0.78 | MAPT (0.50) | MAPTPOLBALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL5842613 | 0.77 | MAPT (0.56) | MAPTPOLBALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL5843721 | 0.76 | MAPT (0.63) | MAPTTP53ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL5842030 | 0.75 | MAPT (0.64) | MAPTALDH1A1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067549-B2 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2006-06-27 | — | — | US | disclosed |