Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 18/20 | 1.00 |
| ▸ | PRKCA | P17252 | 5/20 | 0.66 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.59 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.59 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CCND3 | P30281 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842019 | 1.00 | CDK1 (1.00) | CDK1PRKCACCNB1CCNB2CCNB3 | |
| SCHEMBL29383223 | 1.00 | CDK1 (1.00) | CDK1PRKCACCNB1CCNB2CCNB3 | |
| SCHEMBL5839876 | 0.91 | CDK1 (1.00) | CDK1PRKCAEGFRCCNE1CDK2 | |
| SCHEMBL5839873 | 0.91 | CDK1 (1.00) | CDK1PRKCAEGFRCCNE1CDK2 | |
| SCHEMBL5840346 | 0.91 | CDK1 (1.00) | CDK1PRKCAEGFRCCNE1CDK2 | |
| SCHEMBL6574952 | 0.88 | CDK1 (0.83) | CDK1PRKCACCNB1CCNB2CCNB3 | |
| SCHEMBL6574948 | 0.88 | CDK1 (0.83) | CDK1PRKCACCNB1CCNB2CCNB3 | |
| SCHEMBL7203083 | 0.87 | CDK1 (1.00) | CDK1PRKCACCNB1CCNB2CCNB3 | |
| SCHEMBL5840382 | 0.87 | CDK1 (1.00) | CDK1PRKCACCNB1CCNB2CCNB3 | |
| SCHEMBL5840484 | 0.87 | CDK1 (1.00) | CDK1PRKCACCNB1CCNB2CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | claimed |
| US-20140249165-A1 | PURINE DERIVATIVES FOR TREATMENT OF CYSTIC DISEASES | GENZYME CORPORATION (US) | 2014-09-04 | — | — | US | disclosed |
| US-20140249165-A1 | PURINE DERIVATIVES FOR TREATMENT OF CYSTIC DISEASES | GENZYME CORPORATION (US) | 2014-09-04 | — | — | US | disclosed |
| EP-2617423-A1 | Purine derivatives for the treatment of cystic diseases | GENZYME CORPORATION (US) | 2013-07-24 | — | — | EP | disclosed |
| US-20110046164-A1 | Purine Derivatives for Treatment of Cystic Diseases | GENZYME CORPORATION | 2011-02-24 | — | — | US | disclosed |
| US-20110046164-A1 | Purine Derivatives for Treatment of Cystic Diseases | GENZYME CORPORATION | 2011-02-24 | — | — | US | disclosed |
| WO-2008051502-A1 | PURINE DERIVATIVES FOR THE TREATMENT OF CYSTIC DISEASES | GENZYME CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046164-A1 | Purine Derivatives for Treatment of Cystic Diseases | TYMP, PKD1, CFTR | CDK1 20/4885PRKCA 1327/4885CCNB1 103/4885 |
| US-20140249165-A1 | PURINE DERIVATIVES FOR TREATMENT OF CYSTIC DISEASES | TYMP, PKD1, CFTR | CDK1 20/4885PRKCA 1327/4885CCNB1 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.