Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.43 |
| ▸ | RELA | Q04206 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289639 | 0.88 | NR1H4 (0.46) | POLBHTTAPEX1TDP1NR1H4 | |
| SCHEMBL5842112 | 0.88 | NR1H4 (0.43) | POLBHTTAPEX1TDP1NPC1 | |
| SCHEMBL816059 | 0.86 | HTT (0.45) | POLBHTTAPEX1TDP1NPC1 | |
| SCHEMBL19799417 | 0.86 | POLB (0.61) | POLBHTTAPEX1TDP1NPC1 | |
| SCHEMBL12592442 | 0.86 | POLB (0.61) | POLBHTTAPEX1TDP1NPC1 | |
| SCHEMBL31520182 | 0.86 | POLB (0.61) | POLBHTTAPEX1TDP1NPC1 | |
| SCHEMBL13838124 | 0.85 | POLB (0.60) | POLBHTTAPEX1TDP1NPC1 | |
| SCHEMBL13838060 | 0.85 | POLB (0.60) | POLBHTTAPEX1TDP1NPC1 | |
| SCHEMBL13838100 | 0.85 | POLB (0.60) | POLBHTTAPEX1TDP1NPC1 | |
| SCHEMBL13838106 | 0.85 | POLB (0.60) | POLBHTTAPEX1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11752713-B2 | Polymer composition and methods using said polymer composition to manufacture ophthalmic lens | ESSILOR INTERNATIONAL (FR) | 2023-09-12 | — | — | US | disclosed |
| US-20210072425-A1 | Polymer Composition and Methods Using Said Polymer Composition to Manufacture Ophthalmic Lens | ESSILOR INTERNATIONAL (FR) | 2021-03-11 | — | — | US | disclosed |
| EP-3084484-B1 | POLYMER COMPOSITION AND METHODS USING SAID POLYMER COMPOSITION TO MANUFACTURE OPHTHALMIC LENS | ESSILOR INT (FR) | 2018-03-21 | — | — | EP | disclosed |
| US-20170031059-A1 | Polymer Composition and Methods Using Said Polymer Composition to Manufacture Ophthalmic Lens | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2017-02-02 | — | — | US | disclosed |
| US-20170030898-A1 | Characterization and Directed Evolution of a Methyl Binding Domain Protein for High-Sensitivity DNA Methylation Analysis | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2017-02-02 | — | — | US | disclosed |
| EP-3084484-A1 | POLYMER COMPOSITION AND METHODS USING SAID POLYMER COMPOSITION TO MANUFACTURE OPHTHALMIC LENS | Essilor International (Compagnie Générale D'Optique) (FR) | 2016-10-26 | — | — | EP | disclosed |
| US-7135589-B2 | Monomers for composite resins with acrylates for unsaturated derivative blends with acids, esters for derivatives with low shrinkage | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-11-14 | — | — | US | disclosed |
| US-7094358-B2 | Ultra-low shrinkage composite resins based on blended nematic liquid crystal monomers | THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1373184-B1 | ULTRA-LOW SHRINKAGE COMPOSITE RESINS BASED ON BLENDED NEMATIC LIQUID CRYSTAL MONOMERS | UNIV TEXAS (US) | 2005-12-07 | — | — | EP | disclosed |
| EP-1373184-A4 | ULTRA-LOW SHRINKAGE COMPOSITE RESINS BASED ON BLENDED NEMATIC LIQUID CRYSTAL MONOMERS | UNIV TEXAS (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20040206934-A1 | Ultra-low shrinkage composite resins based on blended nematic liquid crystal secondary monomers | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2004-10-21 | — | — | US | disclosed |
| EP-1373184-A2 | ULTRA-LOW SHRINKAGE COMPOSITE RESINS BASED ON BLENDED NEMATIC LIQUID CRYSTAL MONOMERS | THE UNIVERSITY OF TEXAS SYSTEM (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20030125435-A1 | Ultra-low shrinkage composite resins based on blended nematic liquid crystal monomers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-07-03 | — | — | US | disclosed |
| WO-2002070543-A2 | ULTRA-LOW SHRINKAGE COMPOSITE RESINS BASED ON BLENDED NEMATIC LIQUID CRYSTAL MONOMERS | UNIVERSITY OF TEXAS SYSTEM (US) | 2002-09-12 | — | — | WO | disclosed |