Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | CXCR2 | P25025 | 9/20 | 0.54 |
| ▸ | CXCR1 | P25024 | 6/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846959 | 0.87 | MAPT (0.59) | MAPTCXCR2CXCR1HTTLMNA | |
| SCHEMBL5846252 | 0.84 | MAPT (0.67) | MAPTCXCR2CXCR1LMNATP53 | |
| SCHEMBL5846736 | 0.79 | MAPT (0.70) | MAPTCXCR2CXCR1NPC1LMNA | |
| SCHEMBL5846313 | 0.78 | MAPT (0.78) | MAPTCXCR2CXCR1LMNATP53 | |
| SCHEMBL6850672 | 0.78 | CXCR2 (0.84) | MAPTCXCR2CXCR1 | |
| SCHEMBL5847241 | 0.78 | MAPT (0.68) | MAPTCXCR2CXCR1HTTLMNA | |
| SCHEMBL31173200 | 0.77 | SMN1; SMN2 (0.59) | MAPTNAMPTNPC1MAPK1HTT | |
| SCHEMBL31114389 | 0.77 | SMN1; SMN2 (0.59) | MAPTNAMPTNPC1MAPK1HTT | |
| SCHEMBL23899079 | 0.75 | NAMPT (0.65) | NAMPTNPC1TP53THRBALDH1A1 | |
| SCHEMBL5846964 | 0.75 | MAPT (0.47) | MAPTCXCR2CXCR1NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7151112-B1 | Pharmaceutical uses and synthesis of nicotinamides | UCB SA (GB) | 2006-12-19 | — | — | US | disclosed |
| US-7105690-B2 | Method for producing transition metal compounds and their use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2006-09-12 | — | — | US | disclosed |
| US-6777432-B1 | TREATING A SUBJECT HAVING AN INFLAMMATORY DISORDER ALLEVIATED BY THE INHIBITION OF GRO- ALPHA CYTOKINES | DARWIN MOLECULAR CORPORATION | 2004-08-17 | — | — | US | disclosed |