Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.40 |
| ▸ | HTR2C | P28335 | 10/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846827 | 0.97 | HTR2A (0.41) | HTR2AHTR2CDRD2GPR119HTR2B | |
| SCHEMBL5847563 | 0.91 | HTR2C (0.41) | HTR2AHTR2CDRD2GPR119HTR2B | |
| SCHEMBL5847122 | 0.91 | HTR2C (0.41) | HTR2AHTR2CDRD2GPR119HTR2B | |
| SCHEMBL5847223 | 0.88 | HTR2C (0.41) | HTR2AHTR2CDRD2GPR119HTR2B | |
| SCHEMBL5415796 | 0.87 | HTR2C (0.43) | HTR2AHTR2CDRD2HTR2BHTR1A | |
| SCHEMBL5846925 | 0.87 | HTR2A (0.47) | HTR2AHTR2CDRD2GPR119HTR2B | |
| SCHEMBL5847469 | 0.87 | STS (0.39) | HTR2AHTR2CDRD2GPR119HTR2B | |
| SCHEMBL5847225 | 0.87 | MEN1 (0.39) | HTR2AHTR2CDRD2GPR119HTR2B | |
| SCHEMBL5847380 | 0.87 | HTR2A (0.38) | HTR2AHTR2CDRD2GPR119HTR2B | |
| SCHEMBL5847354 | 0.87 | HTR2A (0.44) | HTR2AHTR2CDRD2GPR119HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |