Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Meclocycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 14/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.77 |
| ▸ | MEN1 | O00255 | 9/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.77 |
| ▸ | USP2 | O75604 | 8/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.77 |
| ▸ | RECQL | P46063 | 7/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.77 |
| ▸ | HPGD | P15428 | 7/20 | 0.77 |
| ▸ | THRB | P10828 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | LMNA | P02545 | 4/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.77 |
| ▸ | CASP7 | P55210 | 2/20 | 0.77 |
| ▸ | CASP1 | P29466 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclocycline SCHEMBL193563 | 1.00 | TDP1 (0.77) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Meclocycline SCHEMBL29365199 | 1.00 | TDP1 (0.77) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Meclocycline SCHEMBL28357495 | 0.89 | TDP1 (0.61) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Meclocycline SCHEMBL24321867 | 0.89 | TDP1 (0.59) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Meclocycline SCHEMBL21133274 | 0.89 | TDP1 (0.59) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Meclocycline SCHEMBL21133273 | 0.89 | TDP1 (0.59) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Meclocycline SCHEMBL3445 | 0.89 | TDP1 (0.59) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Meclocycline SCHEMBL29427550 | 0.89 | TDP1 (0.59) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Meclocycline SCHEMBL195707 | 0.89 | TDP1 (0.59) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Meclocycline SCHEMBL4207351 | 0.88 | TDP1 (0.58) | TDP1KDM4EMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1307971-C | Antimycotic nail varnish composition | POLICHEM SA (LU) | 2007-04-04 | — | — | CN | disclosed |
| US-7033578-B2 | Antimycotic nail varnish composition | POLICHEM S.A. (LU) | 2006-04-25 | — | — | US | disclosed |
| CN-1679472-A | Antimycotic nail varnish composition | POLICHEM SA (LU) | 2005-10-12 | — | — | CN | disclosed |
| CN-1200673-C | Antifungal nail polish composition | POLICHEM SA (LU) | 2005-05-11 | — | — | CN | disclosed |
| EP-1303249-B1 | ANTIMYCOTIC NAIL VARNISH COMPOSITION | POLICHEM SA (LU) | 2004-03-10 | — | — | EP | disclosed |
| US-20040022831-A1 | Antimicotic nail varnish composition | POLICHEM S.A. (LU) | 2004-02-05 | — | — | US | disclosed |
| CN-1449273-A | Antifungal nail polish composition | POLICHEM SA (LU) | 2003-10-15 | — | — | CN | disclosed |
| EP-1303249-A1 | ANTIMYCOTIC NAIL VARNISH COMPOSITION | Polichem S.A. (LU) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002007683-A1 | ANTIMICOTIC NAIL VARNISH COMPOSITION | POLICHEM S.A. (LU) | 2002-01-31 | — | — | WO | disclosed |