Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.60 |
| ▸ | GABRP | O00591 | 6/20 | 0.44 |
| ▸ | GABRD | O14764 | 6/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 6/20 | 0.44 |
| ▸ | GABRE | P78334 | 6/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.44 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2216873 | 0.87 | CNR2 (0.67) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5849849 | 0.86 | TP53 (0.41) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5849331 | 0.84 | CNR2 (0.42) | CNR2ALDH1A1MAPTTSHR | |
| SCHEMBL5849609 | 0.84 | CNR2 (0.40) | CNR2ALDH1A1MAPTTSHR | |
| SCHEMBL7684633 | 0.84 | CNR2 (0.63) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5851464 | 0.84 | HDAC6 (0.43) | CNR2MAPTMEN1KMT2A | |
| SCHEMBL5849866 | 0.82 | CNR2 (0.66) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2214750 | 0.82 | CNR2 (0.71) | CNR2GABRPGABRDGABRA1GABRB1 | |
| Hydrochloric Acid SCHEMBL27908737 | 0.81 | CNR2 (0.70) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL28159270 | 0.81 | CNR2 (0.64) | CNR2GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138408-B2 | HIV integrase inhibitors, pharmaceutical compositions and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2006-11-21 | — | — | US | disclosed |
| US-20060122211-A1 | HIV integrase inhibitors, pharmaceutical compositions and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2006-06-08 | — | — | US | disclosed |
| US-7001912-B2 | HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2006-02-21 | — | — | US | disclosed |
| EP-1590349-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE | PFIZER INC. (US) | 2005-11-02 | — | — | EP | disclosed |
| US-20050165040-A1 | HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2005-07-28 | — | — | US | disclosed |
| WO-2004067531-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE | PFIZER INC. (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122211-A1 | HIV integrase inhibitors, pharmaceutical compositions and methods for their use | POLB, POLA1, TYMP | CNR2 3950/4885GABRP 774/4885GABRD 2265/4885 |
| US-20050165040-A1 | HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use | POLB, APOBEC3C, IDH3A | CNR2 3906/4885GABRP 741/4885GABRD 2082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.