Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846603 | 0.90 | FLT3 (0.41) | FLT3TGFBR1TGFBR2 | |
| SCHEMBL3845849 | 0.89 | KDM4E (0.42) | FLT3TGFBR1NPC1RAB9AMKNK1 | |
| SCHEMBL5853410 | 0.85 | FLT3 (0.36) | FLT3TGFBR1NPC1RAB9AMKNK1 | |
| SCHEMBL3845847 | 0.84 | KDR (0.37) | FLT3TGFBR1NPC1RAB9AMKNK1 | |
| SCHEMBL3848105 | 0.83 | FLT3 (0.44) | FLT3TGFBR1 | |
| SCHEMBL3848398 | 0.83 | FLT3 (0.44) | FLT3TGFBR1 | |
| SCHEMBL3845544 | 0.83 | FLT3 (0.44) | FLT3TGFBR1MKNK1MKNK2 | |
| SCHEMBL3848179 | 0.82 | FLT3 (0.45) | FLT3TGFBR1TGFBR2 | |
| Hydrochloric Acid SCHEMBL3850907 | 0.80 | FLT3 (0.45) | FLT3TGFBR1NPC1RAB9AMKNK1 | |
| SCHEMBL3846088 | 0.80 | FLT3 (0.45) | FLT3NPC1RAB9AMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |