⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767523 | 0.74 | — | — | |
| SCHEMBL578630 | 0.73 | CTNNB1 (0.31) | — | |
| SCHEMBL14780520 | 0.73 | CTNNB1 (0.37) | — | |
| SCHEMBL578979 | 0.72 | CTNNB1 (0.36) | — | |
| SCHEMBL3144908 | 0.72 | CTNNB1 (0.31) | — | |
| SCHEMBL578603 | 0.72 | KCNJ1 (0.32) | — | |
| SCHEMBL14791868 | 0.71 | CTNNB1 (0.33) | — | |
| SCHEMBL2767886 | 0.70 | ERN1 (0.33) | — | |
| SCHEMBL578818 | 0.69 | CTNNB1 (0.36) | — | |
| SCHEMBL14791913 | 0.68 | KDM4E (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102361875-B | 2-hydroxyethyl-1h-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity | ACTELION PHARMACEUTICALS LTD | 2014-08-20 | — | — | CN | disclosed |
| EP-2417141-B1 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2013-10-16 | — | — | EP | disclosed |
| EP-2376497-B1 | 5-AMINO-2-(1-HYDROXY-ETHYL)-TETRAHYDROPYRAN DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-09-18 | — | — | EP | disclosed |
| US-8415375-B2 | 2-hydroxyethyl-1H-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-04-09 | — | — | US | disclosed |
| WO-2013038374-A1 | PROCESS FOR MANUFACTURING A SYNTHETIC INTERMEDIATE | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-21 | — | — | WO | disclosed |
| US-8211890-B2 | 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives | Actelion Pharmaceuticals (CH) | 2012-07-03 | — | — | US | disclosed |
| US-20120040989-A1 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-02-16 | — | — | US | disclosed |
| EP-2417141-A1 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | Actelion Pharmaceuticals Ltd. (CH) | 2012-02-15 | — | — | EP | disclosed |
| US-8071592-B2 | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones | GLAXO GROUP LIMITED (GB) | 2011-12-06 | — | — | US | disclosed |
| CN-102232078-A | 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives | ACTELION PHARMACEUTICALS LTD | 2011-11-02 | — | — | CN | disclosed |
| WO-2008116815-A2 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
| US-20080221110-A1 | Compounds | GLAXO GROUP LIMITED (GB) | 2008-09-11 | — | — | US | disclosed |
| EP-1963324-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2008-09-03 | — | — | EP | disclosed |
| EP-1954697-A2 | PERI CONDENSED TRICYCLIC COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2008-08-13 | — | — | EP | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008003690-A1 | AZATRICYCLIC COMPOUNDS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2008-01-10 | — | — | WO | disclosed |
| WO-2007115947-A1 | PYRROLO-QUINOXALINONE DERIVATIVES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2007-10-18 | — | — | WO | disclosed |
| US-20070185153-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| WO-2007081597-A2 | PERI CONDENSED TRICYCLIC COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007071936-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |