Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A11 | Q9UPY5 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 1/20 | 0.66 |
| ▸ | CA2 | P00918 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | MMP1 | P03956 | 1/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | CASP1 | P29466 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5539370 | 0.84 | SLC7A11 (0.71) | SLC7A11MEN1ABCC3ABCC4USP2 | |
| SCHEMBL29615016 | 0.81 | SLC7A11 (0.82) | SLC7A11MEN1ABCC3ABCC4USP2 | |
| SCHEMBL29720706 | 0.81 | SLC7A11 (0.82) | SLC7A11MEN1ABCC3ABCC4USP2 | |
| SCHEMBL576998 | 0.80 | SLC7A11 (0.65) | SLC7A11MEN1ABCC3ABCC4USP2 | |
| Sulfasalazine SCHEMBL4514 | 0.80 | SLC7A11 (1.00) | SLC7A11MEN1ABCC3ABCC4USP2 | |
| Sulfasalazine SCHEMBL4515 | 0.80 | SLC7A11 (1.00) | SLC7A11MEN1ABCC3ABCC4USP2 | |
| Sulfasalazine SCHEMBL5664970 | 0.80 | SLC7A11 (1.00) | SLC7A11MEN1ABCC3ABCC4USP2 | |
| Sulfasalazine SCHEMBL31174674 | 0.80 | SLC7A11 (1.00) | SLC7A11MEN1ABCC3ABCC4USP2 | |
| Sulfasalazine SCHEMBL10289061 | 0.80 | SLC7A11 (1.00) | SLC7A11MEN1ABCC3ABCC4USP2 | |
| Sulfasalazine SCHEMBL487664 | 0.80 | SLC7A11 (1.00) | SLC7A11MEN1ABCC3ABCC4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418200-A1 | PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF- MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES | EMS S. A. (BR) | 2012-02-15 | — | — | EP | claimed |