Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586110 | 1.00 | KCNH2 (0.44) | KCNH2KCNQ1CACNA1CHTR1ADRD2 | |
| SCHEMBL21878347 | 0.86 | KCNH2 (0.42) | KCNH2KCNQ1CACNA1CHTR1ADRD2 | |
| SCHEMBL21878346 | 0.86 | KCNH2 (0.42) | KCNH2KCNQ1CACNA1CHTR1ADRD2 | |
| SCHEMBL1423300 | 0.84 | SMYD3 (0.41) | KCNH2HTR2A | |
| SCHEMBL1423299 | 0.84 | SMYD3 (0.41) | KCNH2HTR2A | |
| SCHEMBL2798055 | 0.83 | KCNH2 (0.47) | KCNH2KCNQ1CACNA1CHTR1ADRD2 | |
| SCHEMBL603590 | 0.81 | PIK3CA (0.46) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL603591 | 0.81 | PIK3CA (0.46) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL15850919 | 0.78 | KCNA5 (0.43) | KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL707415 | 0.78 | KCNH2 (0.61) | KCNH2KCNQ1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417141-B1 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2013-10-16 | — | — | EP | disclosed |
| US-8415375-B2 | 2-hydroxyethyl-1H-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-04-09 | — | — | US | disclosed |
| US-20120040989-A1 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-02-16 | — | — | US | disclosed |
| EP-2417141-A1 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | Actelion Pharmaceuticals Ltd. (CH) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010116337-A1 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040989-A1 | 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | NQO2, AZI2, Q6ZSR9 | KCNH2 192/4885KCNQ1 44/4885CACNA1C 1679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.