Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.68 |
| ▸ | CCND1 | P24385 | 10/20 | 0.68 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.58 |
| ▸ | CDK9 | P50750 | 8/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.58 |
| ▸ | CDK11A | Q9UQ88 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741662 | 0.90 | CDK4 (0.72) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL5742997 | 0.85 | CDK4 (0.72) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL5741691 | 0.84 | CDK4 (0.71) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL5743010 | 0.84 | CDK4 (0.70) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL5742969 | 0.83 | CDK4 (0.71) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL5743054 | 0.83 | CDK4 (0.85) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL5743411 | 0.83 | CDK4 (0.87) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL5744236 | 0.82 | CDK4 (0.66) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL5743586 | 0.82 | CDK4 (0.75) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL5743774 | 0.82 | CDK4 (0.72) | CDK4CCND1CCNT1CDK9CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094896-B2 | Diaminothiazoles having antiproliferative activity | HOFFMANN-LA ROCHE INC. (US) | 2006-08-22 | — | — | US | disclosed |