Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.82 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MCHR2 | Q969V1 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5862055 | 0.93 | MCHR1 (0.74) | MCHR1OPRK1KCNQ2GAAKMT2A | |
| SCHEMBL5862074 | 0.92 | MCHR1 (0.73) | MCHR1OPRK1KCNQ2GAAKMT2A | |
| SCHEMBL5862031 | 0.90 | MCHR1 (1.00) | MCHR1OPRK1ALDH1A1SMN1; SMN2MCHR2 | |
| SCHEMBL5862827 | 0.89 | MCHR1 (0.98) | MCHR1OPRK1ALDH1A1SMN1; SMN2MCHR2 | |
| SCHEMBL5862204 | 0.86 | MCHR1 (0.63) | MCHR1GAAKMT2AALDH1A1MEN1 | |
| SCHEMBL5862138 | 0.81 | MCHR1 (0.82) | MCHR1KMT2AALDH1A1MEN1GLA | |
| SCHEMBL5860926 | 0.80 | MCHR1 (0.81) | MCHR1KMT2AALDH1A1MEN1GLA | |
| SCHEMBL6069326 | 0.80 | MCHR1 (0.82) | MCHR1OPRK1MCHR2 | |
| SCHEMBL6070315 | 0.79 | MCHR1 (0.81) | MCHR1OPRK1GAAKMT2AMEN1 | |
| SCHEMBL5862100 | 0.77 | MCHR1 (0.77) | MCHR1ALDH1A1SMN1; SMN2MCHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049307-B2 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES (US) | 2006-05-23 | — | — | US | claimed |
| US-20050187279-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBVIE INC. | 2005-08-25 | — | — | US | claimed |
| US-20050137187-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES | 2005-06-23 | — | — | US | claimed |
| US-7049307-B2 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES (US) | 2006-05-23 | — | — | US | disclosed |
| US-20050187279-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBVIE INC. | 2005-08-25 | — | — | US | disclosed |
| US-20050137187-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137187-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | MCHR1 1/4885OPRK1 232/4885KCNQ2 1546/4885 |
| US-20050187279-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | MCHR1 1/4885OPRK1 232/4885KCNQ2 1546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.