Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.71 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863134 | 1.00 | KCNQ3 (0.71) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL5863139 | 1.00 | KCNQ3 (0.71) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL5863224 | 0.94 | KCNQ3 (0.62) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL5863235 | 0.94 | KCNQ3 (0.62) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL5863229 | 0.94 | KCNQ3 (0.62) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL5863194 | 0.93 | KCNQ2 (0.61) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL5863444 | 0.93 | KCNQ2 (0.61) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL5863256 | 0.93 | KCNQ3 (0.61) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL5863452 | 0.93 | KCNQ2 (0.61) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL5863261 | 0.93 | KCNQ3 (0.61) | KCNQ3KCNQ2CYP1A2CYP3A4CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572112-A4 | 3-(PYRIDINYL-PIPERAZIN-1-YL)-PHENYLETHYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL MYERS SQUIBB CO (US) | 2006-12-06 | — | — | EP | claimed |
| US-7087609-B2 | 3-(pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-08 | — | — | US | claimed |
| EP-1572112-A2 | 3-(PYRIDINYL-PIPERAZIN-1-YL)-PHENYLETHYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-09-14 | — | — | EP | claimed |
| WO-2004047745-A2 | 3-(PYRIDINYL-PIPERAZIN-1-YL)-PHENYLETHYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | claimed |
| US-20040110765-A1 | 3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-10 | — | — | US | claimed |
| US-7087609-B2 | 3-(pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| US-20040110765-A1 | 3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110765-A1 | 3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | KCNQ3, KCNQ1, KCNQ2 | KCNQ3 1/4885KCNQ2 3/4885CYP1A2 917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.