Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.67 |
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.60 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865447 | 1.00 | GRM4 (0.67) | GRM4NFE2L2RELAKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL5865400 | 0.98 | GRM4 (0.65) | GRM4NFE2L2RELAKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL5865401 | 0.98 | GRM4 (0.65) | GRM4NFE2L2RELAKDM4ENPC1 | |
| SCHEMBL5865349 | 0.83 | GRM4 (0.71) | GRM4NFE2L2KDM4ENPC1ALDH1A1 | |
| SCHEMBL5865353 | 0.83 | GRM4 (0.71) | GRM4NFE2L2KDM4ENPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5865456 | 0.81 | GRM4 (0.69) | GRM4NFE2L2KDM4ENPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5865459 | 0.81 | GRM4 (0.69) | GRM4NFE2L2KDM4ENPC1ALDH1A1 | |
| SCHEMBL5864824 | 0.80 | GRM4 (1.00) | GRM4KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL5864826 | 0.80 | GRM4 (1.00) | GRM4KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL5864851 | 0.80 | GRM4 (0.67) | GRM4RELAKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034044-B2 | Conjugated aromatic compounds with a pyridine substituent | HOFFMANN-LA ROCHE INC. (US) | 2006-04-25 | — | — | US | disclosed |
| US-20060058354-A1 | Conjugated aromatic compounds with a pyridine substituent | ALANINE ALEXANDER | 2006-03-16 | — | — | US | disclosed |
| US-6951875-B2 | Conjugated aromatic compounds with a pyridine substituent | HOFFMANN-LA ROCHE INC. (US) | 2005-10-04 | — | — | US | disclosed |
| US-20040068118-A1 | Conjugated aromatic compounds with a pyridine substituent | ALANINE ALEXANDER (FR) | 2004-04-08 | — | — | US | disclosed |
| US-20030144525-A1 | Conjugated aromatic compounds with a pyridine substituent | HOFFMANN-LA ROCHE INC. | 2003-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068118-A1 | Conjugated aromatic compounds with a pyridine substituent | GRIN2B, GRIN1, GRIN2C | GRM4 20/4885NFE2L2 1274/4885RELA 1091/4885 |
| US-20030144525-A1 | Conjugated aromatic compounds with a pyridine substituent | GRIN2B, GRIN1, GRIN2C | GRM4 20/4885NFE2L2 1274/4885RELA 1091/4885 |
| US-20060058354-A1 | Conjugated aromatic compounds with a pyridine substituent | GRIN2B, GRIN3A, GRIN2C | GRM4 19/4885NFE2L2 1407/4885RELA 979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.