Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586704 | 1.00 | KMT2A (0.39) | KMT2AMEN1LMNABRD4CREBBP | |
| SCHEMBL582368 | 0.96 | KMT2A (0.41) | KMT2AMEN1LMNAPOLBOPRM1 | |
| SCHEMBL580881 | 0.96 | KMT2A (0.41) | KMT2AMEN1LMNAPOLBOPRM1 | |
| SCHEMBL3083072 | 0.96 | KMT2A (0.41) | KMT2AMEN1LMNAPOLBOPRM1 | |
| SCHEMBL582162 | 0.90 | KMT2A (0.43) | KMT2ABRD4CREBBPPOLBNPSR1 | |
| SCHEMBL3085316 | 0.87 | CHRM1 (0.38) | KMT2AMEN1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL3069035 | 0.87 | CHRM1 (0.38) | KMT2AMEN1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL581176 | 0.87 | CHRM1 (0.38) | KMT2AMEN1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL581342 | 0.87 | NPSR1 (0.43) | KMT2AMEN1NPSR1L3MBTL1SMN1; SMN2 | |
| SCHEMBL3072810 | 0.87 | NPSR1 (0.43) | KMT2AMEN1NPSR1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |