Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 15/20 | 0.61 |
| ▸ | CDK2 | P24941 | 15/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 15/20 | 0.61 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.46 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867600 | 0.88 | CCNA2 (0.60) | CCNA2CDK2CCNA1HDAC3HDAC11 | |
| SCHEMBL5867407 | 0.88 | CCNA2 (0.64) | CCNA2CDK2CCNA1ADCY1HDAC6 | |
| SCHEMBL5867742 | 0.86 | CCNA2 (0.49) | CCNA2CDK2CCNA1HDAC3HDAC11 | |
| SCHEMBL5867828 | 0.86 | CCNA2 (0.49) | CCNA2CDK2CCNA1ADCY1F2 | |
| SCHEMBL5868122 | 0.86 | CCNA2 (0.61) | CCNA2CDK2CCNA1HDAC3HDAC11 | |
| SCHEMBL5867451 | 0.86 | CCNA2 (0.49) | CCNA2CDK2CCNA1ADCY1HDAC6 | |
| SCHEMBL5867670 | 0.86 | CCNA2 (0.59) | CCNA2CDK2CCNA1ADCY1F2 | |
| SCHEMBL5867583 | 0.86 | CCNA2 (0.63) | CCNA2CDK2CCNA1 | |
| SCHEMBL5867954 | 0.84 | CCNA2 (0.54) | CCNA2CDK2CCNA1 | |
| SCHEMBL5867686 | 0.84 | CCNA2 (0.49) | CCNA2CDK2CCNA1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034049-B1 | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents | PHARMACIA ITALIA S.P.A. (IT) | 2006-04-25 | — | — | US | disclosed |
| EP-1202733-B1 | 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-10-05 | — | — | EP | disclosed |
| EP-1202733-A4 | 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2003-05-14 | — | — | EP | disclosed |
| CN-1373662-A | 3(5)-amino-pyrazole derivs., process for their preparation and their use as antitumor agents | PHARMACIA & UP JOHN S P A (IT) | 2002-10-09 | — | — | CN | disclosed |
| EP-1202733-A1 | 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2002-05-08 | — | — | EP | disclosed |
| US-6218418-B1 | THERAPY OF CELL PROLIFERATIVE DISORDERS ASSOCIATED WITH AN ALTERED CELL DEPENDENT KINASE ACTIVITY BY ADMINISTERING AMINO PYRAZOLE DERIVATIVE TO MAMMAL | PHARMACIA & UPJOHN S.P.A (IT) | 2001-04-17 | — | — | US | disclosed |
| WO-2001012189-A1 | 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-02-22 | — | — | WO | disclosed |