Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.62 |
| ▸ | ACE | P12821 | 3/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 2/20 | 0.45 |
| ▸ | FNTB | P49356 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TRHDE | Q9UKU6 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250261 | 1.00 | ACE2 (0.62) | ACE2ACECYP11B1CYP11B2MME | |
| SCHEMBL7222649 | 0.91 | ACE2 (0.62) | ACE2ACECYP11B1CYP11B2IDO1 | |
| SCHEMBL8248307 | 0.91 | ACE2 (0.62) | ACE2ACECYP11B1CYP11B2IDO1 | |
| SCHEMBL5870208 | 0.89 | ACE2 (0.78) | ACE2ACECYP11B1CYP11B2MME | |
| SCHEMBL8248569 | 0.89 | ACE2 (0.78) | ACE2ACECYP11B1CYP11B2MME | |
| SCHEMBL8249070 | 0.87 | ACE (0.58) | ACE2ACECYP11B1CYP11B2MME | |
| SCHEMBL5869812 | 0.87 | ACE (0.58) | ACE2ACECYP11B1CYP11B2MME | |
| SCHEMBL5870473 | 0.84 | ACE2 (0.57) | ACE2ACECYP11B1CYP11B2MME | |
| SCHEMBL8249532 | 0.84 | ACE (0.70) | ACE2ACECYP11B1CYP11B2MME | |
| SCHEMBL5869403 | 0.84 | ACE (0.70) | ACE2ACECYP11B1CYP11B2MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | claimed |
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |