Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | TRHDE | Q9UKU6 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8255755 | 1.00 | MME (0.50) | MMETRHDENPSR1NAALAD2MMP2 | |
| SCHEMBL29448215 | 0.92 | MME (0.43) | MMENPSR1NAALAD2MMP2MMP9 | |
| SCHEMBL8249923 | 0.90 | MME (0.59) | MME | |
| SCHEMBL5870219 | 0.90 | MME (0.59) | MME | |
| SCHEMBL8253955 | 0.89 | MME (0.44) | MMENAALAD2L3MBTL1 | |
| SCHEMBL5869728 | 0.89 | MME (0.44) | MMENAALAD2L3MBTL1 | |
| SCHEMBL3911030 | 0.87 | MME (0.39) | MMENAALAD2 | |
| SCHEMBL3911025 | 0.87 | MME (0.39) | MMENAALAD2 | |
| SCHEMBL10826528 | 0.85 | MME (0.52) | MME | |
| SCHEMBL466340 | 0.85 | GAA (0.40) | MMENAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |