Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.34 |
| ▸ | ACE | P12821 | 3/20 | 0.34 |
| ▸ | GRN | P28799 | 3/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8249119 | 0.88 | ACE2 (0.41) | ACE2ACEGRNSORT1MME | |
| SCHEMBL5870160 | 0.88 | ACE2 (0.41) | ACE2ACEGRNSORT1MME | |
| SCHEMBL8248643 | 0.88 | ACE2 (0.41) | ACE2ACEGRNSORT1MME | |
| SCHEMBL7228586 | 0.83 | ACE2 (0.36) | MMP1ACE2ACEGRNSORT1 | |
| SCHEMBL8249271 | 0.83 | ACE2 (0.36) | MMP1ACE2ACEGRNSORT1 | |
| SCHEMBL5870081 | 0.82 | ELANE (0.38) | ACE2ACEGRNSORT1MME | |
| SCHEMBL7326854 | 0.82 | MME (0.44) | GRNSORT1MMEFOLH1ALDH1A1 | |
| SCHEMBL8249163 | 0.82 | ELANE (0.38) | ACE2ACEGRNSORT1MME | |
| SCHEMBL30628183 | 0.80 | GRN (0.39) | MMP9GRNSORT1MMEFOLH1 | |
| SCHEMBL8249052 | 0.80 | MME (0.36) | MMP1MMP9MMP3ACE2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | claimed |
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |