SCHEMBL5870543

SCHEMBL5870543

CC(=O)C(C(C)=O)C(=O)c1nc2nc(N)[nH]c(=O)c2[nH]1

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PNP P00491 4/20 0.54
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.42
HPGD P15428 1/20 0.42
KMT2A Q03164 1/20 0.42
HSD17B10 Q99714 1/20 0.42
FGFR1 P11362 1/20 0.41
FGFR2 P21802 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL453203 0.85 PNP (0.58) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL218667 0.83 PNP (0.63) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL4446270 0.78 PNP (0.66) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL8843873 0.73 PNP (0.54) PNP
SCHEMBL2940013 0.73 PNP (0.63) PNPKDM4EMEN1ALDH1A1MAPT
8-Aminoguanine SCHEMBL21761 0.73 PNP (1.00) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL6265336 0.73 PNP (0.58) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL3072982 0.72 PNP (0.53) PNPFGFR1FGFR2
SCHEMBL10755112 0.70 PNP (0.50) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL5694187 0.70 FGFR1 (0.57) PNPFGFR1FGFR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112608313-B Treatment method of mother liquor precipitate in production of triacetyl ganciclovir 河北合佳医药科技集团股份有限公司 2023-03-10 CN disclosed
CN-112608313-A Treatment method of mother liquor precipitate in production of triacetyl ganciclovir 河北合佳医药科技集团股份有限公司 2021-04-06 CN disclosed
US-7078524-B2 Process for the synthesis of ganciclovir RANBAXY LABORATORIES LIMITED (US) 2006-07-18 US disclosed
US-20040102628-A1 Process for the synthesis of ganciclovir RANBAXY LABORATORIES LIMITED (IN) 2004-05-27 US disclosed
EP-0806425-B1 An improved regiospecific process for synthesis of acyclic nucleosides LUPIN LAB LTD (IN) 2001-08-29 EP disclosed
US-6043364-A HEATING THE ISOMER IN AN ALKYLATING AGENT IN ABSENCE OF ACID CATALYST AND SOLVENT LUPIN LABORATORIES LIMITED (IN) 2000-03-28 US disclosed
EP-0976751-A1 A process for the isomerisation of an N-7 isomer into an N-9 isomer useful in the synthesis of acyclic nucleosides LUPIN LABORATORIES LIMITED (IN) 2000-02-02 EP disclosed
US-5821367-A REACTING A DIACYLGUANINE AND AN ALKYLATING AGENT IN THE ABSENCE OF AN ACID CATALYST AND A SOLVENT LUPIN LABORATORIES LIMITED (IN) 1998-10-13 US disclosed
EP-0806425-A1 An improved regiospecific process for synthesis of acyclic nucleosides LUPIN LABORATORIES LIMITED (IN) 1997-11-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040102628-A1 Process for the synthesis of ganciclovir TYMP, MTAP, TPMT PNP 10/4885KDM4E 575/4885MEN1 3840/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.