Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.78 |
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.57 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.57 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872889 | 0.89 | MEN1 (0.81) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL1801637 | 0.88 | MEN1 (1.00) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL29356577 | 0.88 | MEN1 (1.00) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5392733 | 0.86 | MEN1 (0.82) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5391354 | 0.86 | MEN1 (0.82) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL6265441 | 0.85 | MEN1 (0.75) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5391642 | 0.84 | MEN1 (0.82) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5385133 | 0.83 | MEN1 (0.77) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5379835 | 0.83 | MEN1 (0.77) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5390931 | 0.82 | MEN1 (0.75) | MEN1KMT2ATDP1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001905-B2 | Substituted diarylamines as MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-02-21 | — | — | US | disclosed |