⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840882 | 0.85 | USP2 (0.50) | — | |
| SCHEMBL783382 | 0.78 | USP2 (0.56) | — | |
| SCHEMBL992170 | 0.76 | TSHR (0.55) | — | |
| SCHEMBL6228102 | 0.76 | — | — | |
| Methanesulfonic Acid Ethyl Ester SCHEMBL5533648 | 0.76 | CA1 (0.53) | — | |
| Methanesulfonic Acid Ethyl Ester SCHEMBL2296 | 0.76 | — | — | |
| SCHEMBL29840591 | 0.76 | USP2 (0.53) | — | |
| SCHEMBL23833996 | 0.74 | TSHR (0.52) | — | |
| SCHEMBL16140792 | 0.74 | TSHR (0.52) | — | |
| SCHEMBL14962984 | 0.74 | USP2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE38934-E1 | Method and reagents for N-alkylating ureides | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-01-10 | — | — | US | claimed |
| US-20040167358-A1 | Method and reagents for N-alkylating ureides | GUTMAN DANIELA (IL) | 2004-08-26 | — | — | US | claimed |
| EP-1027339-B1 | METHOD AND REAGENTS FOR N-ALKYLATING UREIDES | TARO PHARMA IND (IL) | 2004-01-02 | — | — | EP | claimed |
| US-20030018080-A1 | N-methoxymethyl-5,5-diphenylbarbituric acid | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-01-23 | — | — | US | claimed |
| CN-1273581-A | Process and reagent for N-alkylation of ureides | TARO PHARMA IND (IL) | 2000-11-15 | — | — | CN | claimed |
| US-6093820-A | REACTING AN IMIDE WITH A (SUBSTITUTED)ALKOXYALKYLSULFONIC ACID ESTER TO FORM A N-ALKOXYALKYL IMIDE SUCH AS METHOXYMETHYL ETHOSUXIMIDE; ADMINISTERING AS ANTICONVULSANT, ANTIANXIETY AGENT AND MUSCLE RELAXANT | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2000-07-25 | — | — | US | claimed |
| US-9670145-B2 | Process for preparing 1,1-disubstituted ethylene monomers | AFINITICA TECHNOLOGIES, S. L. (ES) | 2017-06-06 | — | — | US | disclosed |
| US-20170022151-A1 | PROCESS FOR PREPARING 1,1-DISUBSTITUTED ETHYLENE MONOMERS | AFINITICA TECHNOLOGIES, S. L. (ES) | 2017-01-26 | — | — | US | disclosed |
| US-RE38934-E1 | Method and reagents for N-alkylating ureides | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-01-10 | — | — | US | disclosed |
| CN-1699349-A | Method and reagents for N-alkylating ureides | TARO PHARMA IND (IL) | 2005-11-23 | — | — | CN | disclosed |
| US-6906079-B2 | Method and reagents for N-alkylating ureides | TARO PHARMACEUTICAL INDUSTRIES LIMITED (IL) | 2005-06-14 | — | — | US | disclosed |
| EP-1027339-B1 | METHOD AND REAGENTS FOR N-ALKYLATING UREIDES | TARO PHARMA IND (IL) | 2004-01-02 | — | — | EP | disclosed |
| US-6664262-B2 | N-methoxymethyl-5,5-diphenylbarbituric acid | TARO PHARMACEUTICALS INDUSTRIES LTD. (IL) | 2003-12-16 | — | — | US | disclosed |
| EP-1342718-A1 | Method and reagents for n-alkylating ureides | TARO PHARMACEUTICAL INDUSTRIES LIMITED (IL) | 2003-09-10 | — | — | EP | disclosed |
| CN-1273581-A | Process and reagent for N-alkylation of ureides | TARO PHARMA IND (IL) | 2000-11-15 | — | — | CN | disclosed |