⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1430631 | 0.86 | — | — | |
| SCHEMBL382836 | 0.85 | — | — | |
| SCHEMBL3469859 | 0.79 | — | — | |
| SCHEMBL27425719 | 0.76 | — | — | |
| SCHEMBL1431003 | 0.73 | — | — | |
| SCHEMBL26981348 | 0.73 | — | — | |
| SCHEMBL26981370 | 0.73 | KCNH2 (0.31) | — | |
| SCHEMBL1515461 | 0.73 | KCNH2 (0.31) | — | |
| SCHEMBL25420170 | 0.72 | — | — | |
| SCHEMBL356585 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917197-A1 | TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2015-09-16 | — | — | EP | claimed |
| CN-104870433-A | Tricyclic compounds and methods of making and using same | ZAFGEN INC | 2015-08-26 | — | — | CN | claimed |
| WO-2014071363-A1 | TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. (US) | 2014-05-08 | — | — | WO | claimed |
| CN-101910158-A | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders | ASTRAZENECA AB | 2010-12-08 | — | — | CN | claimed |
| CN-103764641-B | The tricyclic compound of fractional saturation and preparation and application thereof | 扎夫根股份有限公司 | 2016-10-26 | — | — | CN | disclosed |
| EP-2917197-A1 | TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| CN-104870433-A | Tricyclic compounds and methods of making and using same | ZAFGEN INC | 2015-08-26 | — | — | CN | disclosed |
| WO-2015011252-A1 | PYRIMIDINE-PYRIDINONE SERINE/THREONINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-01-29 | — | — | WO | disclosed |
| US-20150031674-A1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2015-01-29 | — | — | US | disclosed |
| WO-2014071363-A1 | TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. (US) | 2014-05-08 | — | — | WO | disclosed |
| CN-101910158-A | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders | ASTRAZENECA AB | 2010-12-08 | — | — | CN | disclosed |
| US-7105682-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2006-09-12 | — | — | US | disclosed |
| WO-2003062388-A9 | INHIBITION OF RNA FUNCTION | UNIV CALIFORNIA (US) | 2004-05-27 | — | — | WO | disclosed |
| US-20030195230-A1 | Substituted amine derivatives and methods of use | AMGEN INC. | 2003-10-16 | — | — | US | disclosed |
| WO-2003062388-A2 | INHIBITION OF RNA FUNCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-07-31 | — | — | WO | disclosed |