Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.50 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1250431 | 0.90 | MAPT (0.56) | MAPTRAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL444748 | 0.84 | HDAC6 (0.55) | MAPTRAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL19029279 | 0.84 | HDAC6 (0.76) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL19058371 | 0.81 | MAPT (0.71) | MAPTRAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL7610004 | 0.80 | MAPT (0.81) | MAPTRAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL29364254 | 0.80 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL1096761 | 0.80 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL5642041 | 0.78 | MAPT (0.64) | MAPTRAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL19058682 | 0.78 | HDAC6 (0.74) | MAPTRAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL6821226 | 0.78 | MAPT (0.72) | MAPTRAB9ASMN1; SMN2TP53HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045539-B2 | Therapeutic benzoxazole compounds | ASTRAZENECA AB (SE) | 2006-05-16 | — | — | US | claimed |
| US-6420418-B1 | INHIBITION AND PREVENTION OF LEUKOCYTE ADHESION; USED TO TREAT ADHESION-MEDIATED DISEASES SUCH AS ASTHMA, ALLERGIC RHINITIS, MULTIPLE SCLEROSIS; ATHEROSCLEROSIS, AND INFLAMMATORY BOWEL DISEASE | MERCK & CO., INC. | 2002-07-16 | — | — | US | disclosed |
| WO-2001012183-A1 | HETEROCYCLE AMIDES AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 2001-02-22 | — | — | WO | disclosed |