Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873786 | 0.88 | MCHR1 (0.51) | MCHR1KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL5873498 | 0.88 | MCHR1 (0.51) | MCHR1EPHX2 | |
| SCHEMBL5873629 | 0.88 | MCHR1 (0.53) | MCHR1 | |
| SCHEMBL5873632 | 0.88 | MCHR1 (0.53) | MCHR1 | |
| SCHEMBL5873747 | 0.87 | MCHR1 (0.77) | MCHR1 | |
| SCHEMBL5873538 | 0.79 | MCHR1 (0.51) | MCHR1EPHX2MAPTKCNJ6KCNJ3 | |
| SCHEMBL5873527 | 0.79 | MCHR1 (0.52) | MCHR1EPHX2MAPTKCNJ6KCNJ3 | |
| SCHEMBL5873634 | 0.79 | MCHR1 (0.75) | MCHR1 | |
| SCHEMBL5873560 | 0.79 | MCHR1 (0.46) | MCHR1RAB9A | |
| SCHEMBL5873526 | 0.78 | MCHR1 (0.61) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084156-B2 | 2-Aminoquinoline compounds | MERCK & CO., INC. (US) | 2006-08-01 | — | — | US | claimed |
| US-20050026915-A1 | 2-Aminoquinoline compounds | MERCK SHARP & DOHME CORP. | 2005-02-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026915-A1 | 2-Aminoquinoline compounds | MCHR1, MCHR2, MC5R | MCHR1 1/4885MTOR 1452/4885BAZ1A 4397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.