Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873627 | 0.80 | HRH3 (0.52) | MCHR1HRH3CKS1BSKP1SKP2 | |
| SCHEMBL5873487 | 0.75 | MCHR1 (0.57) | MCHR1 | |
| SCHEMBL5873574 | 0.71 | MAP4K4 (0.61) | MCHR1CKS1BSKP1SKP2PDE10A | |
| SCHEMBL5873638 | 0.71 | MCHR1 (0.85) | MCHR1 | |
| SCHEMBL5873513 | 0.71 | MCHR1 (0.85) | MCHR1 | |
| SCHEMBL5873581 | 0.71 | MCHR1 (0.85) | MCHR1 | |
| SCHEMBL29689781 | 0.71 | PDE10A (0.58) | MCHR1CKS1BSKP1SKP2PDE10A | |
| SCHEMBL22499904 | 0.71 | PDE10A (0.58) | MCHR1CKS1BSKP1SKP2PDE10A | |
| SCHEMBL5873546 | 0.70 | MCHR1 (0.56) | MCHR1 | |
| SCHEMBL23387218 | 0.70 | MCHR1 (0.48) | MCHR1HRH3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084156-B2 | 2-Aminoquinoline compounds | MERCK & CO., INC. (US) | 2006-08-01 | — | — | US | disclosed |
| US-20050026915-A1 | 2-Aminoquinoline compounds | MERCK SHARP & DOHME CORP. | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026915-A1 | 2-Aminoquinoline compounds | MCHR1, MCHR2, MC5R | MCHR1 1/4885HRH3 445/4885CKS1B 2663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.