Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 18/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | DRD1 | P21728 | 1/20 | 0.63 |
| ▸ | HRH2 | P25021 | 1/20 | 0.63 |
| ▸ | HTR1B | P28222 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.63 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873777 | 1.00 | MCHR1 (0.68) | MCHR1MAPTCHRM2ADRA2ACHRM1 | |
| Hydrochloric Acid SCHEMBL5873686 | 0.99 | MCHR1 (0.67) | MCHR1MAPTCHRM2ADRA2ACHRM1 | |
| Hydrochloric Acid SCHEMBL5873681 | 0.99 | MCHR1 (0.67) | MCHR1MAPTCHRM2ADRA2ACHRM1 | |
| SCHEMBL5873644 | 0.85 | MCHR1 (0.63) | MCHR1 | |
| SCHEMBL5873650 | 0.85 | MCHR1 (0.63) | MCHR1 | |
| SCHEMBL6204654 | 0.81 | MCHR1 (1.00) | MCHR1MAPT | |
| SCHEMBL6204655 | 0.81 | MCHR1 (1.00) | MCHR1MAPT | |
| SCHEMBL6203995 | 0.79 | MCHR1 (1.00) | MCHR1MCHR2 | |
| SCHEMBL6203989 | 0.79 | MCHR1 (1.00) | MCHR1MCHR2 | |
| SCHEMBL5873520 | 0.78 | MCHR1 (0.74) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084156-B2 | 2-Aminoquinoline compounds | MERCK & CO., INC. (US) | 2006-08-01 | — | — | US | claimed |
| US-20050026915-A1 | 2-Aminoquinoline compounds | MERCK SHARP & DOHME CORP. | 2005-02-03 | — | — | US | claimed |
| EP-1450801-A2 | 2-AMINOQUINOLINE COMPOUNDS | Merck & Co., Inc. (US) | 2004-09-01 | — | — | EP | claimed |
| WO-2003045313-A2 | 2-AMINOQUINOLINE COMPOUNDS | MERCK & CO. INC. (US) | 2003-06-05 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026915-A1 | 2-Aminoquinoline compounds | MCHR1, MCHR2, MC5R | MCHR1 1/4885MAPT 545/4885CHRM2 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.