Sugi Predict

Sugi Predict / Compounds / SCHEMBL5873919

SCHEMBL5873919

SCHEMBL5873919

Cc1cc(=O)[nH]n1-c1ccc(N/C=C2\C(=O)Nc3ncc(-c4ccccc4)cc32)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK3 P52333 1/20 0.38
▸ MAP3K11 Q16584 2/20 0.35
▸ NTRK1 P04629 2/20 0.33
▸ MET P08581 2/20 0.33
▸ MAP4K1 Q92918 2/20 0.33
▸ CHEK1 O14757 1/20 0.33
▸ AURKA O14965 1/20 0.33
▸ DAPK3 O43293 1/20 0.33
▸ PRKD3 O94806 1/20 0.33
▸ MAP4K4 O95819 1/20 0.33
▸ ABL1 P00519 1/20 0.33
▸ CSF1R P07333 1/20 0.33
▸ RET P07949 1/20 0.33
▸ PDGFRB P09619 1/20 0.33
▸ PIM1 P11309 1/20 0.33
▸ FGFR1 P11362 1/20 0.33
▸ PDGFRA P16234 1/20 0.33
▸ FLT1 P17948 1/20 0.33
▸ LTK P29376 1/20 0.33
▸ GRK5 P34947 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5873921 1.00 JAK3 (0.38) JAK3MAP3K11NTRK1METMAP4K1
SCHEMBL5873751 0.88 EPHX2 (0.34) JAK3MAP3K11METPDGFRBPDGFRA
SCHEMBL5873759 0.88 EPHX2 (0.34) JAK3MAP3K11METPDGFRBPDGFRA
SCHEMBL5873770 0.87 RET (0.33) JAK3MAP3K11MAP4K1RET
SCHEMBL5873761 0.87 RET (0.33) JAK3MAP3K11MAP4K1RET
SCHEMBL6880716 0.86 NTRK1 (0.39) NTRK1FLT3ALDH1A1MEN1KMT2A
SCHEMBL6880710 0.86 NTRK1 (0.39) NTRK1FLT3ALDH1A1MEN1KMT2A
SCHEMBL7667897 0.85 KMT2A (0.33) MAP3K11NTRK1ALDH1A1MEN1KMT2A
SCHEMBL5873791 0.84 MAPT (0.40) NTRK1FLT3GSK3BALDH1A1HPGD
SCHEMBL5873788 0.84 MAPT (0.40) NTRK1FLT3GSK3BALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6818632-B2 3-(anilinomethylene)oxindoles SMITHKLINE BEECHAM CORPORATION 2004-11-16 — — US claimed
US-20020099071-A1 Protein tyrosine kinase and protein serin/threonine kinase inhibitory activity; anticancer agents; treating chemotherapy induced alopecia GLENNON KIMBERLEY CAROLINE (US) 2002-07-25 — — US claimed
US-7129253-B2 Compounds SMITHKLINE BEECHAM CORPORATION (US) 2006-10-31 — — US disclosed
US-6818632-B2 3-(anilinomethylene)oxindoles SMITHKLINE BEECHAM CORPORATION 2004-11-16 — — US disclosed
US-6498176-B1 INHIBITING TUMOR GROWTH VIA INHIBITION OF TUMOR-RELATED ANGIOGENESIS SMITHKLINEBEECHAM CORPORATION 2002-12-24 — — US disclosed
US-20020099071-A1 Protein tyrosine kinase and protein serin/threonine kinase inhibitory activity; anticancer agents; treating chemotherapy induced alopecia GLENNON KIMBERLEY CAROLINE (US) 2002-07-25 — — US disclosed
US-6350747-B1 PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS GLAXO WELLCOME INC. 2002-02-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020099071-A1 Protein tyrosine kinase and protein serin/threonine kinase inhibitory activity; anticancer agents; treating chemotherapy induced alopecia PRKDC, PRKX, BMX JAK3 173/4885MAP3K11 97/4885NTRK1 1095/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.