Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.74 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13403347 | 1.00 | AR (0.74) | ARSRD5A2KCNH2 | |
| SCHEMBL5247649 | 1.00 | AR (0.74) | ARSRD5A2KCNH2 | |
| SCHEMBL5116733 | 0.91 | AR (0.74) | ARSRD5A2KCNH2 | |
| SCHEMBL14013760 | 0.91 | AR (0.74) | ARSRD5A2KCNH2 | |
| SCHEMBL7615006 | 0.90 | AR (0.72) | ARSRD5A2KCNH2 | |
| SCHEMBL7614998 | 0.90 | AR (0.72) | ARSRD5A2KCNH2 | |
| SCHEMBL8150406 | 0.89 | AR (0.67) | ARSRD5A2KCNH2 | |
| SCHEMBL5247468 | 0.88 | AR (0.58) | ARSRD5A2KCNH2 | |
| SCHEMBL5339929 | 0.88 | AR (0.58) | ARSRD5A2KCNH2 | |
| SCHEMBL8410044 | 0.88 | AR (0.70) | ARSRD5A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39056-E1 | 4-Azasteroids for treatment of hyperandrogenic conditions | MERCK & CO, INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-6001844-A | 4-Azasteroids for treatment of hyperandrogenic conditions | MERCK & CO., INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0484094-B1 | Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use | SANKYO CO (JP) | 1996-06-26 | — | — | EP | disclosed |
| WO-1994022900-A1 | AZA-ANDROSTANE-17β-CARBOXAMIDES | CIBA-GEIGY AG (CH) | 1994-10-13 | — | — | WO | disclosed |
| US-5304562-A | Inhibitors of 5-alpha-reductase; treating prostate disorders | CIBA-GEIGY CORPORATION (US) | 1994-04-19 | — | — | US | disclosed |
| US-5302621-A | Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use | SANKYO COMPANY, LIMITED (JP) | 1994-04-12 | — | — | US | disclosed |
| US-5237065-A | Steroid 5-alpha-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0277002-B1 | STEROID-5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-17 | — | — | EP | disclosed |
| EP-0484094-A2 | Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use | Sankyo Company Limited (JP) | 1992-05-06 | — | — | EP | disclosed |
| US-5110939-A | Antiandrogens | SMITHKLINE BEECHAM CORPORATION (US) | 1992-05-05 | — | — | US | disclosed |
| US-4888336-A | DECREASE DIHYDROTESTOSTERONE ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1989-12-19 | — | — | US | disclosed |
| EP-0277002-A2 | Steroid-5-alpha-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4220775-A | Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors | MERCK & CO., INC. (US) | 1980-09-02 | — | — | US | disclosed |