Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.55 |
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | CA5A | P35218 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminobenzoic Acid SCHEMBL11323913 | 0.95 | TSHR (0.63) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL9717815 | 0.95 | TSHR (0.71) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Aminobenzoic Acid SCHEMBL8249 | 0.95 | TSHR (0.71) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL7648718 | 0.95 | TSHR (0.71) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Aminobenzoic Acid SCHEMBL1768920 | 0.95 | TSHR (0.71) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Aminobenzoic Acid SCHEMBL10422193 | 0.92 | TSHR (0.60) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Aminobenzoic Acid SCHEMBL28176703 | 0.92 | TSHR (0.60) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Aminobenzoic Acid SCHEMBL23121593 | 0.92 | TSHR (0.67) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Aminobenzoic Acid SCHEMBL9317391 | 0.92 | TSHR (0.67) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Aminobenzoic Acid SCHEMBL25354995 | 0.92 | TSHR (0.67) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762393-B1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | AMGEN INC (US) | 2023-01-11 | — | — | EP | disclosed |
| US-20210047344-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | AMGEN INC. (US) | 2021-02-18 | — | — | US | disclosed |
| EP-3762393-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | Amgen Inc. (US) | 2021-01-13 | — | — | EP | disclosed |
| WO-2019173181-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | AMGEN INC. (US) | 2019-09-12 | — | — | WO | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| EP-0922699-B1 | Asymmetric stilbene compounds useful as sun protection agents | CIBA SC HOLDING AG (CH) | 2004-11-17 | — | — | EP | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-6482241-B1 | Asymmetric stilbene compounds | CIBA SPECIALTY CHEMICALS CORPORATION | 2002-11-19 | — | — | US | disclosed |
| US-6143889-A | Asymmetric stilbene compounds | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0922699-A1 | Asymmetric stilbene compounds useful as sun protection agents | Ciba SC Holding AG (CH) | 1999-06-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047344-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | MCL1, BCL2A1, BCLAF1 | TSHR 4254/4885TP53 80/4885ALDH1A1 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.