Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 6/20 | 0.75 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | PRKCA | P17252 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bis-Imide A SCHEMBL5879127 | 0.86 | CHEK1 (1.00) | CHEK1CDK5CDK5R1GSK3AGSK3B | |
| Bis-Imide A SCHEMBL31061368 | 0.86 | CHEK1 (1.00) | CHEK1CDK5CDK5R1GSK3AGSK3B | |
| SCHEMBL5879218 | 0.82 | CHEK1 (0.50) | CHEK1CDK5CDK5R1DYRK1AGSK3A | |
| SCHEMBL5879196 | 0.79 | CHEK1 (0.50) | CHEK1CDK5CDK5R1DYRK1AGSK3A | |
| SCHEMBL23132393 | 0.76 | CHEK1 (0.73) | CHEK1CDK5CDK5R1DYRK1AGSK3A | |
| SCHEMBL5879158 | 0.75 | CHEK1 (0.71) | CHEK1CDK5CDK5R1GSK3AGSK3B | |
| SCHEMBL5879135 | 0.75 | CHEK1 (0.76) | CHEK1CDK5CDK5R1GSK3AGSK3B | |
| SCHEMBL23132413 | 0.74 | CHEK1 (0.76) | CHEK1CDK5CDK5R1GSK3AGSK3B | |
| SCHEMBL2956909 | 0.73 | CHEK1 (0.69) | CHEK1CDK5CDK5R1GSK3AGSK3B | |
| SCHEMBL5339297 | 0.73 | CHEK1 (0.57) | CHEK1CDK5CDK5R1DYRK1AGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7151108-B2 | Anticarcinogenic, antiproliferative, and antitumor agents | LES LABORATORIES SERVIER (FR) | 2006-12-19 | — | — | US | disclosed |
| EP-1411057-B1 | [3,4-a:3,4-c]carbazole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-04-27 | — | — | EP | disclosed |
| EP-1411057-A1 | [3,4-a:3,4-c]carbazole derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2004-04-21 | — | — | EP | disclosed |