⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14317779 | 1.00 | — | — | |
| SCHEMBL4396564 | 0.96 | — | — | |
| SCHEMBL20220719 | 0.82 | — | — | |
| SCHEMBL15985688 | 0.77 | CYP2C9 (0.30) | — | |
| SCHEMBL13806340 | 0.76 | — | — | |
| SCHEMBL23645789 | 0.75 | — | — | |
| SCHEMBL19730166 | 0.75 | — | — | |
| SCHEMBL19730167 | 0.75 | — | — | |
| SCHEMBL19730154 | 0.74 | — | — | |
| SCHEMBL5138190 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230135894-A1 | MK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20220306604-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2022-09-29 | — | — | US | disclosed |
| US-10292972-B1 | Pharmaceutical composition for treating cancer and a method thereof | KING ABDULAZIZ UNIVERSITY (SA) | 2019-05-21 | — | — | US | disclosed |
| US-20190125732-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER AND A METHOD THEREOF | KING ABDULAZIZ UNIVERSITY (SA) | 2019-05-02 | — | — | US | disclosed |
| US-20160333045-A1 | Preparation of Oligo Conjugates | Emerald Therapeutics, Inc. | 2016-11-17 | — | — | US | disclosed |
| US-9289502-B2 | Preparation of oligo conjugates | Emerald Therapeutics, Inc. (US) | 2016-03-22 | — | — | US | disclosed |
| US-20140256911-A1 | PREPARATION OF OLIGO CONJUGATES | Emerald Therapeutics, Inc. | 2014-09-11 | — | — | US | disclosed |
| US-7022707-B2 | Piperazine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-20040235859-A1 | Novel piperazine derivatives | ADAMS DAVID REGINALD (GB) | 2004-11-25 | — | — | US | disclosed |
| EP-1343775-A2 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-20020143020-A1 | Novel piperazine derivatives | VERNALIS RESEARCH LIMITED (GB) | 2002-10-03 | — | — | US | disclosed |
| WO-2002048124-A2 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-20 | — | — | WO | disclosed |