Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | PDE1A | P54750 | 2/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.43 |
| ▸ | KHK | P50053 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5883465 | 0.99 | PDE5A (0.47) | PDE5APDE1APDE1BPDE1CKHK | |
| SCHEMBL5884000 | 0.97 | PDE5A (0.44) | PDE5APDE1APDE1BPDE1CKHK | |
| SCHEMBL5883665 | 0.97 | PDE5A (0.46) | PDE5APDE1APDE1BPDE1CKHK | |
| SCHEMBL5884388 | 0.97 | PDE5A (0.46) | PDE5APDE1APDE1BPDE1CKHK | |
| SCHEMBL5883962 | 0.97 | PDE5A (0.46) | PDE5APDE1APDE1BPDE1CKHK | |
| SCHEMBL6394807 | 0.92 | PDE5A (0.43) | PDE5APDE1APDE1BPDE1CKHK | |
| SCHEMBL5845071 | 0.90 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CKHK | |
| SCHEMBL5884330 | 0.88 | PDE5A (0.40) | PDE5APDE1APDE1BPDE1CKHK | |
| SCHEMBL5883703 | 0.87 | PDE5A (0.39) | PDE5APDE1APDE1BPDE1CKHK | |
| SCHEMBL5845631 | 0.85 | PDE5A (0.38) | PDE5APDE1APDE1BPDE1CKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087605-B2 | 5-Ethyl-imidazotriazinones | BAYER AKTIENGESELLSCHAFT (DE) | 2006-08-08 | — | — | US | disclosed |
| EP-1397363-B1 | 5-ETHYL-IMIDAZOTRIAZINONES | BAYER HEALTHCARE AG (DE) | 2005-05-11 | — | — | EP | disclosed |
| EP-1397363-A1 | 5-ETHYL-IMIDAZOTRIAZINONES | Bayer HealthCare AG (DE) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098880-A1 | 5-ETHYL-IMIDAZOTRIAZINONES | BAYER HEALTHCARE AG (DE) | 2002-12-12 | — | — | WO | disclosed |