Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.59 |
| ▸ | JAK3 | P52333 | 16/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | MUSK | O15146 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | STAT5B | P51692 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589869 | 0.87 | JAK2 (0.45) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL588501 | 0.86 | JAK2 (0.44) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL588809 | 0.86 | JAK2 (0.44) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL217329 | 0.86 | JAK2 (0.56) | JAK2JAK3NTRK1CDK2MUSK | |
| Phosphoric Acid SCHEMBL589436 | 0.81 | JAK2 (0.41) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL3774509 | 0.81 | JAK2 (0.52) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL589401 | 0.77 | JAK3 (0.62) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL2337030 | 0.76 | KCNH2 (0.44) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL14041700 | 0.74 | JAK2 (1.00) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL14722864 | 0.74 | NTRK1 (0.40) | JAK2JAK3NTRK1CDK2MUSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | claimed |
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | disclosed |